Characterization of the Biosynthetic Potential of the β-proteobacterium Achromobacter xylosoxidans Strain ISP2-142-O-2-A Using Microbiological, Chemical, and Genomic Approaches

This study characterized the biosynthetic potential of the bacterium Achromobacter xylosoxidans strain ISP2-142-O-2-A associated with the sponge Haliclona sp. nov. Chemistry- and bioactivity-guided purification of extracts from A. xylosoxidans afforded three compounds (1–3).

Call for applications: 2019 Bioinformatics Training and Internship Program (Batch 03: Nov-Dec)

Student applicants must be undergraduate or graduate students in good academic standing, enrolled in a science or engineering course at an accredited college or university in the Philippines. Young professional applicants must have a BS degree in a science or engineering field, and be a researcher and/or faculty member employed at a research or higher education institution in the Philippines.

Phenotypic characterization of the novel, non‑hotspot oncogenic KRAS mutants E31D and E63K

KRAS proto‑oncogene, GTPase (KRAS) functions as a molecular switch at the apex of multiple signaling pathways controlling cell proliferation, differentiation, migration, and survival. Canonical KRAS mutants, such as those in codons 12 and 13, produce constitutively active oncoproteins that short‑circuit epidermal growth factor receptor (EGFR)‑initiated signaling, resulting in dysregulated downstream effectors associated with cellular transformation.

Using DNA barcodes against the wildlife black market

While recent news of giant clams (Tridacna gigas) being harvested in the disputed Scarborough Shoal drew massive outrage online, it was only the latest low point in the dark history of wildlife exploitation in the region. A poignant series of cases also happened here in 2013 and 2014, this time involving pangolins or “scaly anteaters,” which have been described as the most trafficked animals in the world.

PGC explores more linkage opportunities with foreign experts

Pals visited the PGC yesterday, March 28th, to see its core facilities and to talk about setting up assays for clinical testing, interpreting genetic testing services, and variant interpretations. He also met with Dr. Cynthia Saloma, PGC executive director; Dr. Raul Destura, PGC health program director; and Dr. Alexander Young, PGC research professor, to discuss the center’s readiness for genetic testing services.