This special issue’s cover is accompanied by the different species covered by the studies in this journal.
Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge Xestospongia sp., with nanomolar IC50s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin (DOX) in estrogen receptor positive MCF-7 breast cancer cells.
This study characterized the biosynthetic potential of the bacterium Achromobacter xylosoxidans strain ISP2-142-O-2-A associated with the sponge Haliclona sp. nov. Chemistry- and bioactivity-guided purification of extracts from A. xylosoxidans afforded three compounds (1–3).
Student applicants must be undergraduate or graduate students in good academic standing, enrolled in a science or engineering course at an accredited college or university in the Philippines. Young professional applicants must have a BS degree in a science or engineering field, and be a researcher and/or faculty member employed at a research or higher education institution in the Philippines.
Scientific research in Mindanao took a big leap last February as the Philippine Genome Center (PGC), a research center of the University of the Philippines (UP) System based in Diliman, Quezon City, established its first satellite facility in the island region.
The program extends to four (4) batches which will be held throughout 2019-2020. The training of the first batch will run from June 17-July 26 , 2019.
KRAS proto‑oncogene, GTPase (KRAS) functions as a molecular switch at the apex of multiple signaling pathways controlling cell proliferation, differentiation, migration, and survival. Canonical KRAS mutants, such as those in codons 12 and 13, produce constitutively active oncoproteins that short‑circuit epidermal growth factor receptor (EGFR)‑initiated signaling, resulting in dysregulated downstream effectors associated with cellular transformation.
A total of 34,958 high-confidence gene models were predicted and functionally associated to various economically important traits, such as pest/disease resistance, drought tolerance, coconut oil biosynthesis, and putative transcription factors.
While recent news of giant clams (Tridacna gigas) being harvested in the disputed Scarborough Shoal drew massive outrage online, it was only the latest low point in the dark history of wildlife exploitation in the region. A poignant series of cases also happened here in 2013 and 2014, this time involving pangolins or “scaly anteaters,” which have been described as the most trafficked animals in the world.
Pals visited the PGC yesterday, March 28th, to see its core facilities and to talk about setting up assays for clinical testing, interpreting genetic testing services, and variant interpretations. He also met with Dr. Cynthia Saloma, PGC executive director; Dr. Raul Destura, PGC health program director; and Dr. Alexander Young, PGC research professor, to discuss the center’s readiness for genetic testing services.