PGC SARS-CoV-2 Bulletin No. 8: Detection of the first 500 SARS-CoV-2 Omicron Variant in the Philippines

This variant, with its more than 30 mutations in the Spike region is hypothesized to be over twice as infectious and twice more likely to escape current vaccines than the Delta variant. Currently, Omicron consists of four (4) phylogenetic lineages: the main lineage B.1.1.529 and its three (3) sublineages: BA.1, BA.2, and BA.3. Based on global statistics, BA.1 is the predominant Omicron lineage being detected worldwide, but a recent increase in the proportion of BA.2 cases has also been observed.

GxB CON 2021: Overcoming Challenges, Building Opportunities

The Philippine Genome Center (PGC) is hosting the Genomics and Bioinformatics Conference 2021 on December 7-9, themed Overcoming Challenges, Building Opportunities—the 3-day conference will consist of talks from experts in health, agriculture, livestock, and fisheries as well as in biodiversity, ethnicity, and forensics.

DOST, UP to inaugurate cutting-edge analytical facility for proteomics research

The new facility under the supervision of Dr. Neil Andrew D. Bascos, has been preparing for this much-awaited launch since last year. Together with his team of young researchers, they have been working on standardizing and optimizing laboratory protocols, and establishing research networks, to promote the use of multi-Omics technologies throughout the Philippines.

Response to the 09 June 2021 statement of Dr. Maximilian Larena and Prof. Mattias Jakobson on the conduct of their Genomic Study on the Filipino Past

Since the Philippine Genome Center is mentioned and we have received numerous queries from colleagues in the country and the region, we are compelled to issue this Statement to address the following:
– the possible inference (from the way the Statement is written) that the head of the Philippine Genome Center’s (PGC) Program on Forensics and Ethnicity connived with the National Commission on Indigenous Peoples (NCIP) and Philippine Health Ethics Research Board (PHREB) against Dr. Larena and Prof. Jakobsson’s research or is responsible for their actions; and
– the imputation that the ethical issues raised by these agencies and PGC aim to discredit “good research” because the head of PGC’s Program on Forensics and Ethnicity is pursuing similar genetic research.

PGC Mindanao engages in a collaborative SARS-COV-2 genomics study using a portable sequencing platform

The Oxford Nanopore MinION is a portable sequencer and has the lowest instrument cost among all sequencing platforms with a 97.5 to >99.3% raw read accuracy (Oxford Nanopore Technologies, 2021). The technology has demonstrated its utility for sequencing biological entities, from the simple nano-sized viruses to complex plants and animals, generating sequence information that is sufficient to provide comprehensive insights into the underlying genome architecture. It has also been validated to produce SARS-CoV-2 consensus sequences with the same accuracy as other sequencing platforms (Bull et al., 2020 and Charre et al., 2020).

In Vitro Lipid-lowering Properties of the Fruits of Two Bignay [Antidesma bunius (L.) Spreng] Cultivars as Affected by Maturity Stage and Thermal Processing

Bignay [Antidesma bunius (L). Spreng] fruit contains an array of polyphenols and information on how these bioactive compounds vary with cultivar type, maturity stage, and process treatment are unclear. Also, the effects of these variations on the lipid-lowering potential of this Philippine indigenous berry have not been reported.

PGC SARS-CoV-2 Bulletin No. 7: Detection and characterization of a new SARS-CoV-2 lineage P.3, with spike protein mutations E484K, N501Y, P681H and LGV 141-143 deletion, from samples sequenced through the intensified UP-PGC, UP-NIH and DOH biosurveillance program

A close examination of the mutation profile of the P.3 viruses revealed that apart from E484K and N501Y, they also share other spike protein mutations that are likely to have functional significance (Figure 2). This includes the P681H mutation, also found in lineage B.1.1.7 viruses, as well as a three-amino acid deletion at positions 141 to 143 (LGV141_143del).