Phenotypic characterization of the novel, non‑hotspot oncogenic KRAS mutants E31D and E63K

KRAS proto‑oncogene, GTPase (KRAS) functions as a molecular switch at the apex of multiple signaling pathways controlling cell proliferation, differentiation, migration, and survival. Canonical KRAS mutants, such as those in codons 12 and 13, produce constitutively active oncoproteins that short‑circuit epidermal growth factor receptor (EGFR)‑initiated signaling, resulting in dysregulated downstream effectors associated with cellular transformation.

Using DNA barcodes against the wildlife black market

While recent news of giant clams (Tridacna gigas) being harvested in the disputed Scarborough Shoal drew massive outrage online, it was only the latest low point in the dark history of wildlife exploitation in the region. A poignant series of cases also happened here in 2013 and 2014, this time involving pangolins or “scaly anteaters,” which have been described as the most trafficked animals in the world.

Call for applications: 2019 Bioinformatics Training and Internship Program

The internship program will be held on June 17 to July 26, 2019 at the 2nd floor, Left Wing, Philippine Genome Center Building, A. Ma. Regidor St., University of the Philippines, Diliman, Quezon City. Interested individuals from public and private colleges, universities, and research institutions nationwide are invited to apply. A stipend will be provided to help cover travel and living expenses.

PGC explores more linkage opportunities with foreign experts

Pals visited the PGC yesterday, March 28th, to see its core facilities and to talk about setting up assays for clinical testing, interpreting genetic testing services, and variant interpretations. He also met with Dr. Cynthia Saloma, PGC executive director; Dr. Raul Destura, PGC health program director; and Dr. Alexander Young, PGC research professor, to discuss the center’s readiness for genetic testing services.