Genomics for a better Philippines


The Philippine Genome Center (PGC), a genomics-focused multidisciplinary research unit of the University of the Philippines (System) is located at the PGC Building, A. Maria Regidor Street, National Science Complex, University of the Philippines, Diliman, Quezon City. PGC offers a full range of DNA sequencing services from single gene sequencing to high-throughput sequencing and a suite of Bioinformatics services from scripting to full project workflows. In fulfilling its mandates, the PGC welcomes collaborations on research, capacity building, and institutional linkages for the development of genome-based applications.

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The Novel Phosphatase Domain Mutations Q171R and Y65S…

Jose Antonio Ma. G. Garrido, Krizelle Mae M. Alcantara, Joshua Miguel C. Danac, Fidel Emmanuel C. Serrano, Eva Maria Cutiongco-de la Paz, Reynaldo L. Garcia Abstract Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K–Akt pathway. Large datasets from next-generation sequencing, however, revealed that mutations in PTEN may not only hamper protein function but may also affect interactions with downstream effectors, leading to variable oncogenic readouts. Here, two novel PTEN mutations, Q171R and Y65S, identified in Filipino colorectal cancer patients, were phenotypically characterized in NIH3T3 and HCT116 cells, alongside the C124S canonical mutant and wild-type controls. The novel mutants increased cellular proliferation, resistance to apoptosis and migratory capacity. They induced gross morphological changes including cytoplasmic shrinkage, increased cellular protrusions and extensive cytoskeletal reorganization. The mutants also induced a modest increase in Akt phosphorylation. Further mechanistic studies will help determine the differential oncogenic potencies of these mutants, and resolve whether ...
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NEWS & EVENTS


GxB CON 2021: Overcoming Challenges, Building Opportunities
The Philippine Genome Center (PGC) is hosting the Genomics and Bioinformatics Conference 2021 on December 7-9, themed Overcoming Challenges, Building ...
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#PGCTalks – PPMF Webinar
Expanding the Field of Omics Research in the Philippines: A Glimpse into the World of Proteins, Proteomics, and Metabolomics#PGCTalks REGISTER ...
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DOST, UP to inaugurate cutting-edge analytical facility for…
The Department of Science and Technology (DOST) and the University of the Philippines (UP) will inaugurate the Protein, Proteomics, and ...
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Response to the 09 June 2021 statement of…
The Statement of Dr. Maximilian Larena and Prof. Mattias Jakobsson asserts that the  National Commission on Indigenous Peoples (NCIP) and ...
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