The PGC-Core Facility for Bioinformatics is inviting Filipino college students and young professionals in science and engineering for an online training and internship program in bioinformatics.
The PGC Core Facility for Bioinformatics, together with Noveaulab and PacBio, are conducting a two-day online training workshop on the bioinformatics analysis of 16S metagenomic data using PacBio reads. This event will be held on April 18-19, 2022 (Mon-Tue) at 1:00-5:00 PM. Interested individuals from public and private colleges, universities, and research institutions in the […]
Eight SNPs were found to be associated with the development of SLE among Filipinos. Similar to previous genetic studies in lupus patients, majority of the SNPs were found in the major histocompatibilty complex genes in the HLA region. Our study identified two unique SNPs that will be validated as potential diagnostic markers for SLE. The findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.
This variant, with its more than 30 mutations in the Spike region is hypothesized to be over twice as infectious and twice more likely to escape current vaccines than the Delta variant. Currently, Omicron consists of four (4) phylogenetic lineages: the main lineage B.1.1.529 and its three (3) sublineages: BA.1, BA.2, and BA.3. Based on global statistics, BA.1 is the predominant Omicron lineage being detected worldwide, but a recent increase in the proportion of BA.2 cases has also been observed.
The Philippine Genome Center (PGC) is hosting the Genomics and Bioinformatics Conference 2021 on December 7-9, themed Overcoming Challenges, Building Opportunities—the 3-day conference will consist of talks from experts in health, agriculture, livestock, and fisheries as well as in biodiversity, ethnicity, and forensics.
HPC and Data Science Workflow in Julia #PGCTalks Date: July 16, 2021, Friday, 4:30-6:00pm This webinar is open to the public and registration is free. Abstract Julia is specifically designed from the start of its conception as a language for high-performance computation but at the same time highly interactive. To achieve this, Julia is one […]
Coronavirus disease 2019 (COVID-19) is an infectious disease that has gained pandemic status from the World Health Organization, with millions of cases and deaths recorded worldwide. This global health crisis is caused by the virus referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the genus Betacoronavirus (Coronaviridae), together with the causative agents of the first SARS outbreak in 2003 and the Middle East respiratory syndrome (MERS) in 2012.
A close examination of the mutation profile of the P.3 viruses revealed that apart from E484K and N501Y, they also share other spike protein mutations that are likely to have functional significance (Figure 2). This includes the P681H mutation, also found in lineage B.1.1.7 viruses, as well as a three-amino acid deletion at positions 141 to 143 (LGV141_143del).
Through the biosurveillance efforts of the UP – Philippine Genome Center (PGC), in coordination with the Department of Health (DOH) – Epidemiology Bureau and the Inter-Agency Task Force (IATF) Task Force on COVID-19 Variants, we report the first confirmed case of the SARS-CoV-2 B.1.1.7 lineage, more commonly known as the UK variant, in the Philippines. An announcement of this finding can be found in an official DOH press release dated January 13, 2021.
Recently, new SARS-CoV-2 variants were detected in the United Kingdom and South Africa with multiple spike protein mutations that may cause substantial changes in certain properties of the virus. These observations spurred biosurveillance efforts in different countries, with some countries outside of the UK and South Africa already reporting the presence of these new variants within their territories. The data presented in this report is part of our own continuing biosurveillance efforts to track the entry of these new variants in the country, as well as other viral mutations that may be of concern locally.