The efficacy of monoclonal antibodies targeting the epidermal growth factor receptor (EGFR) pathway for treatment of colorectal cancer (CRC) depends on predictive biomarkers that can identify likely responders or non-responders to therapy.
Draft Genome Sequence of Multidrug-Resistant Vibrio parahaemolyticus Strain PH698, Infecting Penaeid Shrimp in the Philippines
The emergence of multidrug-resistant bacterial strains in diverse settings has been reported globally. In the Philippine shrimp aquaculture industry, antibiotics are used for the treatment of bacterial diseases during the production cycle. We report the draft genome of Vibrio parahaemolyticus PH698, a multidrug-resistant strain isolated from a Philippine shrimp farm.
Draft Genome Sequence of Vibrio parahaemolyticus Strain PH1339, Which Causes Acute Hepatopancreatic Necrosis Disease in Shrimp in the Philippines
Acute hepatopancreatic necrosis disease (AHPND), which affects multiple shrimp species, including the economically important Penaeus monodon and Penaeus vannamei, is characterized by massive sloughing of the epithelial cells of the hepatopancreas to the point of atrophy (1).
Plant cytogenomics in the post-genomics era
The release of the first human reference genome in 2003 marked the beginning of the post-genomics era when genetics progressed beyond gene-centered analyses to a myriad of omics approaches. Genome sequencing technologies have advanced dramatically from Sanger, second/next-generation, to third-generation sequencing platforms. Also, genome assembly methods and tools have evolved contemporaneously, resulting in a dramatic drop in genome assembly cost. Consequently, more than 360 plant species’ genomes have been assembled ever since the first plant genome, Arabidopsis thaliana, was published in 2000.
“Oh, my Genes”: Lessons from Plant Genetics and Genomics for Trait Improvement
In recent years, genetics and genomics has played an important role in facilitating the genetic improvement of plants. Different tools have been developed to examine the structure, function, and properties of genes controlling complex traits. The genetic diversity of germplasm found in existing gene banks through different breeding populations such as core collections, nested association mapping panels, mutants, recombinant inbred lines, and multiparent advance generation intercross populations in germplasm banks served as sources of desirable alleles for plant breeding.
Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells
Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge Xestospongia sp., with nanomolar IC50s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin (DOX) in estrogen receptor positive MCF-7 breast cancer cells.
Characterization of the Biosynthetic Potential of the β-proteobacterium Achromobacter xylosoxidans Strain ISP2-142-O-2-A Using Microbiological, Chemical, and Genomic Approaches
This study characterized the biosynthetic potential of the bacterium Achromobacter xylosoxidans strain ISP2-142-O-2-A associated with the sponge Haliclona sp. nov. Chemistry- and bioactivity-guided purification of extracts from A. xylosoxidans afforded three compounds (1–3).
Using DNA barcodes against the wildlife black market
While recent news of giant clams (Tridacna gigas) being harvested in the disputed Scarborough Shoal drew massive outrage online, it was only the latest low point in the dark history of wildlife exploitation in the region. A poignant series of cases also happened here in 2013 and 2014, this time involving pangolins or “scaly anteaters,” which have been described as the most trafficked animals in the world.
PGC hosts One Health Bioinformatics and Grant Writing Workshop
This skill building workshop aims to freely integrate available molecular data from global repositories that are pertinent to locally circulating pathogens and apply it to research areas of interest for both the Biological Threat Reduction Program of the US government thru the Defense Threat Reduction Agency.
Strategic Planning with the PGC Agriculture Team
The Strategic Planning with the PGC Agriculture team was facilitated by PGC’s newly appointed Deputy Executive Director, Dr. Raul Destura. The activity was initiated by the PGC main office in order to weave the 6-year sustainability plan of the entire PGC.