Non-additive effects of ACVR2A in preeclampsia in a Philippine population

Multiple interrelated pathways contribute to the pathogenesis of preeclampsia, and variants in susceptibility genes may play a role among Filipinos, an ethnically distinct group with high prevalence of the disease. The objective of this study was to examine the association between variants in maternal candidate genes and the development of preeclampsia in a Philippine population

Whole genome sequencing and single nucleotide polymorphisms in multi-drug resistant clinical isolates of Mycobacterium tuberculosis from the Philippines

Thousands of cases of multi-drug resistant Mycobacteria tuberculosis (MTB) have been observed in the Philippines but studies on the genotypes that underlie the observed drug resistance profiles have been lacking. This study aimed to analyse whole genomes of clinical isolates of MTB representing varying resistance profiles to identify single nucleotide polymorphisms (SNPs) in resistance-associated genes.

PGC researchers attend annual Human Genetics Meeting

Mr. Garrido and Ms. Alcantara shared the preliminary findings of the two Philippine Genome Center’s projects, “Mutational analysis of KRAS, NRAS, PIK3CA, BRAF, and PTEN genes in Filipino Colorectal Cancer Patients,” and “Detection and Functionalization of KRAS, NRAS, PIK3CA, BRAF, and PTEN Gene Mutations in Filipino Colorectal Cancer Patients,” through poster presentations.