cheryl_andam

A tale of sex: gene sharing between microbial species, genomes and microbiomes

Horizontal gene transfer (HGT) is an important evolutionary process that allows the spread of innovations between distantly related organisms. In this webinar, I will present recent findings on the process, driving factors and impacts of HGT in light of recent developments in next-generation sequencing approaches. I will discuss examples of HGT within species, between species and between microbial communities, and how these gene exchange networks drive the genetic and phenotypic diversity of microbes in nature and clinical settings

ido_goldstein

Transcription Factor Assisted Loading and Enhancer Dynamics Dictate the Hepatic Fasting Response

Fasting elicits transcriptional programs in hepatocytes leading to glucose and ketone production. This transcriptional program is regulated by many transcription factors (TFs). To understands how this complex network regulates the metabolic response to fasting we aimed at isolating the enhancers and TFs dictating it. Measuring chromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous fasting-induced enhancers.