Whole genome sequencing and single nucleotide polymorphisms in multi-drug resistant clinical isolates of Mycobacterium tuberculosis from the Philippines

Thousands of cases of multi-drug resistant Mycobacteria tuberculosis (MTB) have been observed in the Philippines but studies on the genotypes that underlie the observed drug resistance profiles have been lacking. This study aimed to analyse whole genomes of clinical isolates of MTB representing varying resistance profiles to identify single nucleotide polymorphisms (SNPs) in resistance-associated genes.

jong_de_castro

Medical Records in the Genomic Era

Dr. de Castro has a PhD in Biochemistry and Genetics (University of Texas Medical Branch), but also trained in the Neurosciences (California Institute of Technology, The Burnham Institute). His current work and interests lie in Cancer Immunology (3R Biosystems), and an advocacy for equitable access to health technologies (UnEMR). He is a Biomedical Informatics consultant of the International Atomic Energy Agency (IAEA) and a Balik Scientist under a joint research informatics project between UP Manila and UPLB. He has an B.S. MBB degree from UP Diliman.