In this review, we highlight the necessity for biodiversity biorepositories by presenting their significant role in health, biodiversity, linking of big data, other translational research, and biodiversity conservation efforts.
Eight SNPs were found to be associated with the development of SLE among Filipinos. Similar to previous genetic studies in lupus patients, majority of the SNPs were found in the major histocompatibilty complex genes in the HLA region. Our study identified two unique SNPs that will be validated as potential diagnostic markers for SLE. The findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.
Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K–Akt pathway.
This special issue’s cover is accompanied by the different species covered by the studies in this journal.