MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle

The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction.

A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3

Cleft palate (CP) is a common birth defect occurring in 1 in 2,500 live births. Approximately half of infants with CP have a syndromic form, exhibiting other physical and cognitive disabilities. The other half have nonsyndromic CP, and to date, few genes associated with risk for nonsyndromic CP have been characterized.

Advancing Cryptosporidium Diagnostics from Bench to Bedside

Cryptosporidium is increasingly being recognized as an important cause of diarrhea worldwide. Although well known for its impact among HIV positive population, improved diagnostic tests have contributed to its emerging recognition one among the most prevalent causes of early childhood moderate to severe diarrhea, persistent diarrhea, and impaired neurocognitive development.