Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K–Akt pathway.
![](https://pgc.up.edu.ph/wp-content/uploads/2021/07/High-rates-of-tenofovir-failure-in-a-CRF01_AE-predominant-HIV-epidemic-in-the-Philippines.jpg)
High rates of tenofovir failure in a CRF01_AE-predominant HIV epidemic in the Philippines
The Philippines has the fastest growing HIV epidemic in the Asia-Pacific. This increase was accompanied by a shift in the predominant HIV subtype from B to CRF01_AE. Increasing evidence points to a difference in treatment responses between subtypes. We examined treatment failure and acquired drug resistance (ADR) in people living with HIV (PLHIVs) after one year on antiretrovirals (ARVs).