Makapuno is a coconut cultivar with a naturally overproliferating solid endosperm almost filling the nut cavity. At 6-7 months after pollination (MAP), makapuno solid endosperm is phenotypically indistinguishable from the normal type Laguna Tall while at 8-9 MAP makapuno starts to soften and thicken in contrast to the hard and compact appearance of the normal. Here, the expression profiles of 6-7 and 8-9 MAP de novo assembled RNA Sequencing (RNA-Seq) transcriptomes of normal and makapuno were analyzed, and corresponding stages were compared to determine the differentially expressed genes (DEGs).