Kinetic Capillary Electrophoresis – a Swiss Army Knife for Studying Kinetics of Protein-DNA Interactions

Protein-DNA interactions play an important role in gene expression, DNA replication, DNA integrity control, and DNA damage repair. Understanding the mechanisms of these processes requires the knowledge of kinetics (rate constants) of reversible Protein-DNA binding. Electrophoresis has been the workhorse method for in vitro studies of such interactions.


Opportunities and challenges in plant genomics: Shaping a Philippine Plant Genome Research Program

Genomic technologies coupled with new computational approaches have led to new insights into the genomes of key plant species, particularly agriculturally important crops. We will discuss some general opportunities for plant genome research in the Philippines, and illustrate some of these with examples from my laboratory’s work on Asian and African rice and date palms.


IT Governance: a simple solution to the complex problem of building national scale health information systems

Information and communications technology has become pervasive in many sectors, health included. Yet rather than streamlining health processes, it seems ICT only serves to add to the fragmentation with the creation of more information silos. Improperly implemented, ICT can introduce new risks and additional complexity to an already overworked sector. Emerging from the chaos is IT Governance, a that encourages the use of frameworks to guide stakeholders from the many confusing elements of a health information system.


Functional inference from protein-protein interaction networks: issues, quality checks, and possible solutions

This talk focuses functional inference of confirmed influenza A host factors whose role(s) in the infection are not clear. Here, we explore the impact of various parameters on network neighbourhood approaches in functional elucidation. In particular, we investigate the sources of degeneracy and false positives for solutions obtained from two integrative protein-protein interaction databases, STRING ( and HIPPIE ( Finally, we present edge- and vertex-annotation-based filtering solutions that restrict the graph to the most context-relevant network neighbourhoods.