Date: Tuesday, 31 May 2016, 10 am (Manila Time)
Abstract
I will describe my work with the NCI TARGET Pediatric Acute Myeloid Leukemia consortium in which we are integrating data from 197 cancer whole genome sequences with mRNA and miRNA expression and DNA-methylation data, including verification of DNA variants via targeted re-sequencing, and frequency validation of confirmed variants in 650 additional patients. I will show how pathway analysis confirms many known features of pediatric AML and leads to significant new discoveries. I will end by describing our development of computational methods and software that use cancer genomics data to stratify patients for precision medicine.
Dr. Hamid Bolouri
Research faculty member, Division of Human Biology,
Fred Hutchinson Cancer Research Center, Seattle, USA.
Bolouri Lab
About the Speaker
Hamid Bolouri received his PhD in Microelectronic Systems Architecture from Brunel University (UK) in 1990. He is currently a Research faculty member in the Division of Human Biology at the Fred Hutchinson Cancer Research Center, Seattle, USA. Before taking up his current post, Bolouri was Professor of Computational Biology at the Institute for Systems Biology, Seattle, USA, Professor of Neural Systems at the University of Hertfordshire, UK, and visiting associate faculty at the California Institute of Technology.
Bolouri is the author of “Personal Genomics and Personalized Medicine” (Imperial College Press, 2010) and “Computational modeling of gene regulatory networks – a primer” (Imperial College Press, 2008). He led the early development of several computational biology resources, including the Systems Biology Markup Language (currently used by over 250 software packages) and the BioArray gene expression analysis suite, which was licensed to Genetix Plc. (UK) in 2001. He is the recipient of the 2010 SPIE Systems Biology Pioneer Award.
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