CellMiner databases, tools, and molecular pharmacologic applications

Understanding the influences of molecular alterations on pharmacological responses in the omic sense is at the fore of the effort to make oncology treatments more effective and specific. At present, however, this remains a field in its infancy. The NCI-60 cancerous cell lines provide a premier set of databases and tools for systems molecular pharmacological studies.


Overview of the Galaxy platform for analysis of genomics data

Modern genomics research requires complex computational processing to integrate, analyze, and extract meaning from large, disparate datasets. While a multitude of commercial and open source bioinformatics applications are available, it is difficult to assemble a collection of tools that work together seamlessly to perform the required analysis. Even more difficult is performing analysis in a manner that documents the data, algorithms, and processing steps such that the results are easily published and reproducible.


Deciphering how proteins engage the genome and direct cellular identities

All cells in our bodies encode the same genetic information yet different sets of genes are expressed in a given cell type to give it its particular identity. My laboratory studies how transcription factors (TFs) recognize genomic DNA to regulate when, where and to which level genes are expressed to direct cell fate decisions. We use structural modelling and quantitative biochemical assays to study TF dimerization on composite binding elements enriched in regulatory DNA sequences.


IT Governance: a simple solution to the complex problem of building national scale health information systems

Information and communications technology has become pervasive in many sectors, health included. Yet rather than streamlining health processes, it seems ICT only serves to add to the fragmentation with the creation of more information silos. Improperly implemented, ICT can introduce new risks and additional complexity to an already overworked sector. Emerging from the chaos is IT Governance, a that encourages the use of frameworks to guide stakeholders from the many confusing elements of a health information system.