Deciphering how proteins engage the genome and direct cellular identities

All cells in our bodies encode the same genetic information yet different sets of genes are expressed in a given cell type to give it its particular identity. My laboratory studies how transcription factors (TFs) recognize genomic DNA to regulate when, where and to which level genes are expressed to direct cell fate decisions. We use structural modelling and quantitative biochemical assays to study TF dimerization on composite binding elements enriched in regulatory DNA sequences.