Functional inference from protein-protein interaction networks: issues, quality checks, and possible solutions

This talk focuses functional inference of confirmed influenza A host factors whose role(s) in the infection are not clear. Here, we explore the impact of various parameters on network neighbourhood approaches in functional elucidation. In particular, we investigate the sources of degeneracy and false positives for solutions obtained from two integrative protein-protein interaction databases, STRING ( and HIPPIE ( Finally, we present edge- and vertex-annotation-based filtering solutions that restrict the graph to the most context-relevant network neighbourhoods.